Alternatively, liver dysfunction occurring among women on OCs may be responsible for reduced metabolism of warfarin, contributing to the effectiveness of the anticoagulation. Although this finding has not been reported in women on OCs, it may be that the estrogen-induced "lability" of the prothrombin complex occurs in humans only in special conditions, such as anticoagulation. After 1 treatment for only 1 estral cycle, OC-treated rats had a significantly longer Normotest clotting time (37.7+ or-0.5 sec) than control rats (31.0+or-0.4) the difference was even more notable after 10 cycles. A study of prothrombin complex activity was recently conducted in female rats treated with an estrogen-progestogen combination (lynestrenol 5 mg mestranol 0.3 mg/kg body weight) which resulted in a 100% infertility in this species. De Teresa and others reported that mean prothrombin time ratio of 12 patients on long-term anticoagulation with warfarin was significantly higher when they were also taking oral contraceptives (OCs).
Pangrazzi, J Roncaglioni, M C Donati, M Bĭr. Oral contraceptives and the prothrombin time. 864.7720 Section 864.7720 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages § 864.7720 Prothrombin. 21 Food and Drugs 8 false Prothrombin consumption test.
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Chronic complication of DM (microangiopathy and macroangiopathy accured because endotel dysfunction which caused by various pathogenesis, such as hyperglycemia, oxydative stress, upregulation of free fatty acid, Protein Kinase C β and insulin secretion defectĢ1 CFR 864.7720 - Prothrombin consumption test. Hasil pengukuran tersebut menunjukkan tidak terdapat hubungan antara hiperglikemia dan prothrombin time (p > 0,05.Kata kunci: hiperglikemia, diabetes mellitus, prothrombin time, aloksan.AbstractDiabetes mellitus have two complication, they are acute and chronic complication. Hasil menunjukkan terdapat pemendekan PT pada kedua kelompok penelitian dengan rerata PT kelompok control adalah 7,96 detik dan kelompok hiperglikemia adalah 8,12 detik. Pada hari ke 30 dilakukan terminasi untuk mengukur PT mencit. Setelah adaptasi selama tujuh hari, dilakukan injeksi aloksan serta pemeriksaan glukosa darah dan berat badan tiap empat hari sekali. Subjek penelitian adalah mencit putih (Musmusculus yang telah memenuhi criteria inklusi dan eksklusi, kemudian dibagi menjadi kelompok hiperglikemia (diinjeksikan aloksan dan kelompok kontrol. Desain penelitian ini adalah post test only control group design yang dilaksanakan dari Oktober 2013 hingga Februari 2014 di Laboratorium Sentral RS. Kerusakan pembuluh darah (disfungsi endotel tersebut dapat dideteksi melalui pemeriksaan activated partial prothrombin time (APTT dan prothrombin time (PT yang berperan dalam mekanisme homeostasis padatubuh.Tujuan penelitian ini adalah untuk melihat hubungan hiperglikemia dengan prothrombin time pada mencit putih (Musmusculus yang diinduksi aloksan. Komplikasi kronik DM (mikroangiopati dan makroangiopati terjadi akibat disfungsi endotel yang disebabkan oleh berbagai proses pathogenesis yaitu hiperglikemia, stres oksidatif, peningkatan jumlah asam lemak bebas, Protein Kinase C β dan defek sekresi insulin. Hubungan Hiperglikemia dengan Prothrombin Time pada Mencit (Mus musculus yang Diinduksi Aloksanĭirectory of Open Access Journals (Sweden)įull Text Available AbstrakDiabetes mellitus mempunyai dua macam komplikasi yaitu komplikasi akut dan kronik. Most of the time, results are given as what is called INR (. PT Pro- time Anticoagulant- prothrombin time Clotting time: protime INR International normalized ratio. 864.7750 Section 864.7750 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES HEMATOLOGY AND PATHOLOGY DEVICES Hematology Kits and Packages § 864.7750 Prothrombin time. 21 Food and Drugs 8 false Prothrombin time test.
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